![]() ![]() ![]() ![]() This sequence of events leads to a decreased vascular cross-sectional area, increased vascular resistance, and increased blood pressure.Īmlodipine works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. The vascular smooth muscle contraction becomes further amplified by calcium-induced calcium release from the sarcoplasmic reticulum. MLCK is responsible for the phosphorylation of myosin light-chain, ultimately leading to muscle contraction and vasoconstriction. ![]() The calcium binds to intracellular calmodulin, which binds to and activates myosin light-chain kinase (MLCK). Normally, vascular smooth muscle contraction initiates when calcium enters the cell via voltage-dependent L-type calcium channels. ![]()
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